Is Ciprofloxacin a Substrate of P-glycoprotein?
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Is Ciprofloxacin a Substrate of P-glycoprotein?
INTRODUCTION: Studies using MDCKII and LLC-PK1 cells transfected with MDR1 cDNA indicate that ciprofloxacin is not a substrate of P-glycoprotein. However, our data has shown that transport studies done using different P-gp overexpressing cell lines (MDCKI-MDR1, MDCKII-MDR1 and L-MDR1), could lead to contradictory conclusion on whether a compound is a substrate of P-gp. The aim of our study was ...
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ژورنال
عنوان ژورنال: Archives of Drug Information
سال: 2010
ISSN: 1753-5174
DOI: 10.1111/j.1753-5174.2010.00032.x